The responses of adult parasympathetic ganglion neurons to injury and the neurotrophic mechanisms underlying their axonal regeneration are poorly understood. This is especially relevant to penis-projecting parasympathetic neurons, which are vulnerable to injury during pelvic surgery such as prostatectomy. We investigated the changes in pelvic ganglia of adult male rats in the first week after unilateral cavernous penile nerve axotomy cut or crush lesions.
Skip to search form Skip to main content. Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between streptozotocin-treated rats and man.
Erectile dysfunction ED or impotence is the most common of the various sexual dysfunctions, and because multiple advances have been realized in understanding the physiologic and biochemical mechanisms involving penile erection and in clinical techniques of improving ED, this chapter will be devoted primarily to the sexual dysfunction of impotence. Erectile dysfunction or impotence is the consistent inability to achieve or sustain an erection of sufficient rigidity to permit satisfactory sexual intercourse 1. It has been estimated from data collected in that 10 million American males, or approximately 1 in 10 men, have impotence 12.
Systemic administration of apomorphine induced both penile erection and yawning in non-diabetic rats but not in diabetic rats, while that of physostigmine induced only yawning in non-diabetic rats, and neither yawning nor penile erection in diabetic rats. Intracerebroventricular administration of VIP induced both penile erection and yawning in non-diabetic rats, but neither was induced in diabetic rats. Application of VIP as an ointment to the surface of the glans penis induced penile erection but not yawning in both non-diabetic and diabetic rats.
Penile erection is a part of the human male sexual response, involving desire, excitation erectionorgasm ejaculationand resolution, and autonomic nerves are involved in all phases. Autonomic innervation of smooth-muscle cells of the erectile tissue is provided by the cavernous nerve. Motor and sensory innervation is derived from the pudendal nerves and their terminal branches, that is, the dorsal nerves of the penis, which carry impulses from receptors harbored in the penile skin, prepuce, and glans.
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Sign in. VILAS. Abstract: The present study was designed to characterize the response of human penile dorsal artery and deep dorsal vein to dilator drugs used in the diagnosis and treatment of erectile dysfunction with special emphasis on the effects on sympathetic neurotransmission. Ring segments of penile dorsal artery and deep dorsal vein were obtained from 20 multi-organ donors during procurement of organs for transplantation.
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Investigative Urology 2 pp Cite as. Vasoactive intestinal polypeptide VIPa amino acid polypeptide, was first isolated from the human gut by Said and Mutt and is believed to possess all characteristics of a neurotransmitter. Recent studies have shown that the distribution of this neuropeptide is ubiquitous, mainly in the genitourinary tract Larsson et al.